The ancient and powerful Dr. Mist has summoned the Super Friends and a team of allies of theirs from around the world for an urgent mission. A new evildoer named the Conqueror has captured six of the world’s greatest villains, and the Super Friends now have to help their old foes escape before the Conqueror gains their secrets and absolute power.

Doctor Mist summons the Super Friends to his base of operations. He also transport several international heroes who would later join him as members of the Global Guardians. He enlists their aid in apprehending a new villain who has captured other villains in an attempt to steal their weapons.

Wonder Woman and Godiva rescue Queen Bee, who was imprisoned in a hive. Batman and Bushmaster come to the aid of Kanjar Ro who and Aquaman and Little Mermaid free Sinestro who is off shore and under the see in an energy trap without his ring. After the 3 villains are rescued, the Conqueror is monitoring their progress and reveals his ultimate plan to use the captured weapons to enslave Dr. Mist.

In the back-up story, Plastic Man battle Rubberneck and Putty Face in "One of our Barbarians is Missing."